Animal Dosing Vehicle Selection

Choosing an optimal vehicle for animal PK and Tox studies requires multidisciplinary skillsets and a sound understanding of the physicochemical properties of your compound. Controlling solid and solution variability of your vehicle is critical to yielding consistent and coherent PK data.

Crystal Pharmatech ensures quality PK data in your studies by gaining an understanding of:

• Crystal form of API being dosed

• Particle attributes of API being dosed

• Chemical and physical stability

• Gavageability

• Propensity to aggregate

• Biorelevant dissolution throughout the GI tract

These factors play a vital role in ensuring you can rely on your PK data. Programs that are driven almost entirely by in-vivo guesswork are prone to backtracking. Controlling variability and ensuring quality data are vital to making quicker, smarter decisions.